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Proteintech
USP3 Polyclonal Antibody
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Product Details
12490-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
USP3 Fusion Protein Ag3085 (1-300 aa encoded by BC018113)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MECPHLSSS VCIAPDSAKF PNGSPSSWCC SVCRSNKSPW VCLTCSSVHC GRYVNGHAKK HYEDAQVPLT NHKKSEKQDK VQHTVCMDCS SYSTYCYRCD DFVVNDTKLG LVQKVREHLQ NLENSAFTAD RHKKRKLLEN STLNSKLLKV NGSTTAICAT GLRNLGNTCF MNAILQSLSN IEQFCCYFKE LPAVELRNGK TAGRRTYHTR SQGDNNVSLV EEFRKTLCAL WQGSQTAFSP ESLFYVVWKI MPNFRGYQQQ DAHEFMRYLL DHLHLELQGG FNGVSRSAIL QENSTLSASN K (1-300 aa encoded by BC018113)
Target Information
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Deubiquitinating enzyme 3; Ubiquitin carboxyl-terminal hydrolase 3; Ubiquitin thioesterase 3; ubiquitin thiolesterase 3; Ubiquitin-specific-processing protease 3; unnamed protein product
Gene Aliases: AA409661; BC017156; SIH003; UBP; USP3
UniProt ID: (Human) Q9Y6I4, (Mouse) Q91W36
Entrez Gene ID: (Human) 9960, (Mouse) 235441
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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