The recommended shelf life for this product is 1 year from date of receipt.
p73 protein is a member of the p53 family of proteins. The tumor-suppressor protein p53 exhibits sequence specific DNA-binding, directly interacts with various cellular and viral proteins, and induces cell cycle arrest in response to DNA damage. In response to signals generated by a variety of genotoxic stresses, e.g, UV irradiation or DNA damage, p53 is expressed and undergoes post-translational modification that results in its accumulation in the nucleus. Activation of p53 leads to cell cycle arrest and in some cases to apoptosis, resulting in the inability of genetically damaged cells to proliferate. Thus, the p53-dependent pathways help to maintain genomic stability by eliminating damaged cells. The accumulation of high levels of p53 is a potential marker for malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Deubiquitinating enzyme 35; Ubiquitin carboxyl-terminal hydrolase 35; ubiquitin specific protease 35; Ubiquitin thioesterase 35; ubiquitin thiolesterase 35; Ubiquitin-specific-processing protease 35
Gene Aliases: KIAA1372; USP34; USP35
UniProt ID: (Human) Q9P2H5
Entrez Gene ID: (Human) 57558
Molecular Function: cysteine protease