May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4).
Protein Aliases: Deubiquitinating enzyme 36; Ubiquitin carboxyl-terminal hydrolase 36; ubiquitin specific protease 36; Ubiquitin thioesterase 36; Ubiquitin-specific-processing protease 36
Gene Aliases: DUB1; KIAA1453; USP36
UniProt ID: (Human) Q9NVC8
Entrez Gene ID: (Human) 57602
Molecular Function: cysteine protease