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Proteintech
USP37 Polyclonal Antibody
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Product Details
18465-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
USP37 Fusion Protein Ag12513 (1-351 aa encoded by BC112901)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLTLQDNSF LSIDKVPSKD AEEMRLFLDA VHQNRLPAAM KPSQGSGSFG AILGSRTSQK ETSRQLSYSD NQASAKRGSL ETKDDIPFRK VLGNPGRGSI KTVAGSGIAR TIPSLTSTST PLRSGLLENR TEKRKRMIST GSELNEDYPK ENDSSSNNKA MTDPSRKYLT SSREKQLSLK QSEENRTSGL LPLQSSSFYG SRAGSKEHSS GGTNLDRTNV SSQTPSAKRS LGFLPQPVPL SVKKLRCNQD YTGWNKPRVP LSSHQQQQLQ GFSNLGNTCY MNAILQSLFS LQSFANDLLK QGIPWKKIPL NALIRRFAHL LVKKDICNSE TKKDLLKKVK NAISATAERF SG (1-351 aa encoded by BC112901)
Target Information
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Deubiquitinating enzyme 37; tmp_locus_50; Ubiquitin carboxyl-terminal hydrolase 37; ubiquitin specific peptidase 37; ubiquitin specific peptidase 37-like; ubiquitin specific protease 37; Ubiquitin thioesterase 37; ubiquitin thiolesterase 37; Ubiquitin-specific-processing protease 37; usp37
Gene Aliases: 4932415L06Rik; C330008N13Rik; KIAA1594; USP37
UniProt ID: (Human) Q53S10, (Mouse) Q8C0R0
Entrez Gene ID: (Human) 57695, (Mouse) 319651, (Rat) 100361658
G1/S transition of mitotic cell cycle
ubiquitin-dependent protein catabolic process
mitotic nuclear division
protein deubiquitination
protein K11-linked deubiquitination
cell division
protein K48-linked deubiquitination
proteolysis
cell cycle
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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