Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). [UniProt]
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Protein Aliases: Deubiquitinating enzyme 37; tmp_locus_50; Ubiquitin carboxyl-terminal hydrolase 37; ubiquitin specific peptidase 37; ubiquitin specific peptidase 37-like; ubiquitin specific protease 37; Ubiquitin thioesterase 37; ubiquitin thiolesterase 37; Ubiquitin-specific-processing protease 37; usp37
Gene Aliases: 4932415L06Rik; C330008N13Rik; KIAA1594; USP37