PA5-31074 targets USP46 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-31074 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 213 of Human USP46.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).
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Protein Aliases: Deubiquitinating enzyme 46; Ubiquitin carboxyl-terminal hydrolase 46; ubiquitin specific protease 46; Ubiquitin thioesterase 46; ubiquitin thiolesterase 46; Ubiquitin-specific-processing protease 46
Gene Aliases: 1190009E20Rik; 2410018I08Rik; AI451644; USP46