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Bethyl Laboratories
USP47 Polyclonal Antibody
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FIGURE: 1 / 4
USP47 Antibody (IHC-00235) in IHC (P)
Detection of human USP47 by immunohistochemistry. Sample: FFPE section of human prostate adenocarcinoma. Antibody: Affinity purified rabbit anti-USP47 (Product # IHC-00235) used at a dilution of 1:100. Detection: Red-fluorescent Alexa Fluor® 555 goat anti-rabbit IgG (Invitrogen) used at a dilution of 1:500.
Product Details
IHC-00235
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1237 and the C-terminus (residue 1287) of Human ubiquitin specific peptidase 47.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Chicken, Turkey, Bovine, Dog, Rabbit, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee and Naked mole rat
Target Information
Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme 47; Trf (TATA binding protein-related factor)-proximal homolog; Ubiquitin carboxyl-terminal hydrolase 47; ubiquitin specific protease 47; Ubiquitin thioesterase 47; ubiquitin thiolesterase 47; Ubiquitin-specific-processing protease 47; unnamed protein product
Gene Aliases: 4930502N04Rik; A630020C16Rik; TRFP; USP47
UniProt ID: (Human) Q96K76, (Mouse) Q8BY87
Entrez Gene ID: (Human) 55031, (Mouse) 74996
DNA repair
base-excision repair
proteolysis
cellular response to DNA damage stimulus
intrinsic apoptotic signaling pathway in response to DNA damage
protein deubiquitination
regulation of protein stability
monoubiquitinated protein deubiquitination
positive regulation of canonical Wnt signaling pathway
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
ubiquitin-dependent protein catabolic process
negative regulation of G2/M transition of mitotic cell cycle
positive regulation of cell growth
cellular response to UV
response to drug
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of transcription, DNA-templated
regulation of proteasomal protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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