Immunogen sequence: GQKQDTPVRR GRTLRSMASG EDVVLPQRAP QGQPQMLTAL WYRRQRLLAR TLRLWFEKSS RGQAKLEQRR QEEALERK
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 88%.
Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
Protein Aliases: Deubiquitinating enzyme 49; Ubiquitin carboxyl-terminal hydrolase 49; ubiquitin specific protease 49; Ubiquitin thioesterase 49; ubiquitin thiolesterase 49; Ubiquitin-specific-processing protease 49
Gene Aliases: USP49
UniProt ID: (Human) Q70CQ1
Entrez Gene ID: (Human) 25862
Molecular Function: cysteine protease