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Invitrogen
USP51 Polyclonal Antibody
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FIGURE: 1 / 3
USP51 Antibody (PA5-68358) in WB
Molecular medicine reports 2020 -
Figure 4. Knockdown of USP51 decreases DDP resistance in A549/DDP cells by modulating ZEB1 ubiquitination. (A) After infection of ZEB1/vector lentivirus in A549/DDP cells, ZEB1 mRNA and protein levels were detected. (B) A549/DDP cells were infected with shUSP51 and ZEB1 lentiviruses and treated with 100 umol/l DDP, and apoptotic cells were detected. (C) ZEB1 mRNA expression in USP51-silenced A549/DDP cells ... View More
Product Details
PA5-68358
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human USP51.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Human, Mouse, and Rat samples.
Target Information
USP51 (Ubiquitin Specific Peptidase 51) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Deubiquitinating enzyme 51; Ubiquitin carboxyl-terminal hydrolase 51; ubiquitin specific peptidase 51; ubiquitin specific protease 51; Ubiquitin thioesterase 51; ubiquitin thiolesterase 51; Ubiquitin-specific-processing protease 51
Gene Aliases: AV136873; RGD1562211; USP51
UniProt ID: (Human) Q70EK9, (Mouse) B1AY15
Entrez Gene ID: (Human) 158880, (Mouse) 635253, (Rat) 317398
DNA repair
proteolysis
cellular response to DNA damage stimulus
regulation of cell cycle process
regulation of double-strand break repair via homologous recombination
protein deubiquitination
DNA repair-dependent chromatin remodeling
regulation of double-strand break repair via nonhomologous end joining
regulation of transcription, DNA-templated
histone deubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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