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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Genomic peptide made to an internal region of the human Usp9X protein (within residues 1150-1300).|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.1% BSA, 30% glycerol|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The target sequence has 95% sequence homology with rat and 80% sequence homology with zebrafish.
USP9X is an ubiquitin-specific protease involved in the removal and recycling of ubiquitin from proteins degraded in proteasomes. As a deubiquitinating enzyme, USP9x has a critical function in tight junction biogenesis by controlling the levels of the exchange factor for Arf6 (EFA6), a protein shown to facilitate tight junction formation during a narrow temporal window preceding the establishment of cell polarity (1). USP9X is also located on the X-chromosome but escapes X-inactivation, and defects in USP9X may cause gonadal degeneration in Turner syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
deubiquitinating enzyme FAF-X; DFFRX; Drosophila fat facets related; Drosophila fat facets related, X-linked; FAF; FAM; fat facets homolog; fat facets in mammals; fat facets protein related; fat facets protein related, X-linked; fat facets protein-related; fat facets protein-related, X-linked; fats facets protein related, X; hFAM; probable ubiquitin carboxyl-terminal hydrolase FAF-X; ubiquitin carboxyl-terminal hydrolase FAM; ubiquitin specific protease 9; ubiquitin specific protease 9 SSSRF- isoform; ubiquitin specific protease 9, X chromosome; ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila); ubiquitin thioesterase FAF-X; ubiquitin thiolesterase FAF-X; ubiquitin-specific processing protease FAF-X; ubiquitin-specific protease 9; ubiquitin-specific protease 9, X chromosome; ubiquitin-specific-process; ubiquitin-specific-processing protease FAF-X; X chromosome; X chromosome (fat facets-like Drosophila); X-linked
5730589N07Rik; AA407302; AA407699; AL022658; AL022749; DFFRX; FAF; FAF-X; Fafl; FAM; MRX99; MRXS99F; USP9; USP9X