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Product Details
PA5-53531
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human UTS2
Conjugate
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2649380
Product Specific Information
Immunogen sequence: TNVFHLMLCV TSARTHKSTS LCFGHFNSYP SLPLIHDLLL EISFQLSAPH EDARLTPEEL ERASLLQILP EMLGAERGDI LRKADSSTNI FNPRGNLRKF QDFSGQDPNI LLSHLLARIW KPYKKRETPD CFWKYCV
Highest antigen sequence identity to the following orthologs: Mouse - 37%, Rat - 34%.
Target Information
Urotensin II is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: prepro U-II; U-II; Urotensin II; Urotensin-2
Gene Aliases: PRO1068; U-II; UCN2; UII; UNQ525/PRO1068; UTS2
UniProt ID: (Human) O95399
Entrez Gene ID: (Human) 10911
response to hypoxia
negative regulation of glomerular filtration
muscle contraction
positive regulation of cytosolic calcium ion concentration
chemical synaptic transmission
regulation of blood pressure
negative regulation of heart rate
positive regulation of heart rate
positive regulation of fibroblast migration
positive regulation of circadian sleep/wake cycle, wakefulness
positive regulation of synaptic transmission, cholinergic
positive regulation of collagen biosynthetic process
response to testosterone
negative regulation of urine volume
negative regulation of renal sodium excretion
response to drug
positive regulation of cell differentiation
positive regulation of angiogenesis
negative regulation of blood pressure
positive regulation of blood pressure
positive regulation of vasodilation
positive regulation of circadian sleep/wake cycle, REM sleep
negative regulation of insulin secretion
positive regulation of fibroblast proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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