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QED Bioscience
UVRAG Polyclonal Antibody
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Product Details
23013-100UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to mid-protein amino acids of human UVRAG.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
UVRAG is predicted to contain a coiled-coil structure and is likely to be metabolically unstable based on the occurrence of a strong PEST domain. It interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenicity of human colon cancer cells. The gene for UVRAG protein is localized on human chromosome 11q13. 5 and complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. The gene has been extremely well conserved during evolution, implying an important role for this gene product in cell metabolism. Chromosomal aberrations involving this gene are associated with left-right axis malformation, and mutations in this gene have been associated with colon cancer. The protein is highly expressed in human brain, lung, kidney and liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beclin 1 binding protein; disrupted in heterotaxy; p63; UV radiation resistance-associated gene protein
Gene Aliases: DHTX; p63; UVRAG; VPS38
UniProt ID: (Human) Q9P2Y5
Entrez Gene ID: (Human) 7405, (Rat) 308846
DNA repair
retrograde vesicle-mediated transport, Golgi to ER
autophagy
spindle organization
chromosome segregation
positive regulation of autophagy
regulation of cytokinesis
receptor catabolic process
SNARE complex assembly
viral entry into host cell
centrosome organization
maintenance of Golgi location
regulation of vesicle-mediated transport
regulation of protein serine/threonine kinase activity
multivesicular body sorting pathway
autophagosome maturation
double-strand break repair via classical nonhomologous end joining
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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