UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
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Protein Aliases: beclin 1 binding protein; disrupted in heterotaxy; p63; UV radiation resistance-associated gene protein; UV radiation resistance-associated protein; UVRAG
Gene Aliases: 9530039D02Rik; AI648770; BB124205; DHTX; p63; UVRAG; Uvrag1; Uvragl; VPS38