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OriGene
UVRAG Polyclonal Antibody
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Product Details
TA590654
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DNA immunization. This antibody is specific for the C Terminus Region of the target protein.
Conjugate
Form
Liquid
Concentration
0.77737 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
UVRAG is predicted to contain a coiled-coil structure and is likely to be metabolically unstable based on the occurrence of a strong PEST domain. It interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenicity of human colon cancer cells. The gene for UVRAG protein is localized on human chromosome 11q13. 5 and complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. The gene has been extremely well conserved during evolution, implying an important role for this gene product in cell metabolism. Chromosomal aberrations involving this gene are associated with left-right axis malformation, and mutations in this gene have been associated with colon cancer. The protein is highly expressed in human brain, lung, kidney and liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beclin 1 binding protein; disrupted in heterotaxy; p63; unnamed protein product; UV radiation resistance-associated gene protein
Gene Aliases: DHTX; p63; UVRAG; VPS38
UniProt ID: (Human) Q9P2Y5
Entrez Gene ID: (Human) 7405
DNA repair
retrograde vesicle-mediated transport, Golgi to ER
autophagy
cellular response to DNA damage stimulus
spindle organization
chromosome segregation
centrosome cycle
regulation of autophagy
vesicle-mediated transport
regulation of cytokinesis
receptor catabolic process
SNARE complex assembly
phosphatidylinositol-3-phosphate biosynthetic process
protein-containing complex subunit organization
viral entry into host cell
maintenance of Golgi location
regulation of protein serine/threonine kinase activity
multivesicular body sorting pathway
autophagosome maturation
double-strand break repair via classical nonhomologous end joining
positive regulation of autophagosome maturation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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