Immunogen sequence: LSAMSNPRAM QALMQIQQGL QTLATEAPGL IPSFTPGVGV GVLGTAIGPV GPVTPIGPIG PIVPFTPIGP IGPIGPTGPA APPGSTGSGG PTGPTVSSAA PSETTSPTSE SGPNQQFIQQ MVQALAGANA PQLPNPEVRF QQQLEQLN
Dsk2 increases the half-life of proteins destined to be degraded by the proteasome, and may modulate proteasome-mediated protein degradation. The Dsk2 protein binds UBE3A and BTRC, and interacts with the 19S proteasome subunit. In the cytoplasm, Dsk2 colocalizes with the proteasome; it is also associated with fibers in mitotic cells in the nucleus. Dsk2 is highly expressed in mitotic cells from metaphase to telophase, while expression in non-mitotic cells is very low.
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Protein Aliases: Chap1; CHAP1/DSK2; Dsk2; DSK2 homolog; N4BP4; Nedd4 binding protein 4; PLIC-2; PLIC2; Protein linking IAP with cytoskeleton 2; RIHFB2157; Ubiquilin-2; Ubiquitin-like product Chap1/Dsk2
Gene Aliases: ALS15; CHAP1; DSK2; HRIHFB2157; N4BP4; PLIC2; UBQLN2
UniProt ID: (Human) Q9UHD9
Entrez Gene ID: (Human) 29978