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Proteintech
Uromodulin Polyclonal Antibody
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Product Details
32657-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Concentration
450 µg/mL
Amount
67.5 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: NSTEARRCSE CHNNATCTVD GVVTTCSCQT GFTGDGLVCE DMDECATPWT HNCSNSSCVN TPGSFKCSCQ DGFRLTPELS CTDVDECSEQ GLSNCHALAT CVNTEGDYLC VCPEGFTGDG WYCECSPGSC EPGLDCLPQG PDGKLVCQDP CNTYETLTEY WRSTEYGVGY SCDAGLHGWY RFTGQGGVRM AETCVPVLRC NTAAPMWLNG SHPSSSEGIV SRTACAHWSD QCCRWSTEIQ VKACPGGFYI YNLTAPPECN LAYCTDPSSV EGTCEECRVD EDCISDNGRW RCQCKQDSNI TDVSQLEYRL ECGANDIKMS LRKCQLQSLG FMNVFMYLND RQCSGFSESD ERDWMSIVTP ARNGPCGTVL RRNETHATYS NTLYLANAII IRDIIIRMNF ECSYPLDMKV SLKTSLQPMV SALNISLGGT GKFTVRMALF QSPTYTQPHQ GPSVMLSTEA FLYVGTMLDG GDLSRFVLLM TNCYATPSSN STDPVKYFII QDSCPRTEDT TIQVTENGES SQARFSVQMF RFAGNYDLVY LHCEVYLCDS TSEQCKPTCS GTRFRSGNFI DQTRVLNLGP ITRQGVQASV SKAA
Target Information
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Tamm-Horsfall urinary glycoprotein; THP; Uromodulin; uromucoid; uromucoid uromucoid
Gene Aliases: THP; Umod; Urehd1; urehr4
UniProt ID: (Mouse) Q91X17
Entrez Gene ID: (Mouse) 22242
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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