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Uteroglobin Antibody (500-P330-100UG) in WB
Western Blot: To detect Human Uteroglobin by Western Blot analysis Uteroglobin Polyclonal Antibody (Product # 500-P330-1MG) can be used at a concentration of 0.1-0.2 µg/mL. When used in conjunction with compatible secondary reagents, the detection limit for Recombinant Human Uteroglobin is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
Product Details
500-P330-100UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived Recombinant Human Uteroglobin
Conjugate
Form
Lyophilized
Concentration
0.1-1.0 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
RRID
AB_2930455
Product Specific Information
AA Sequence of recombinant protein: MEICPSFQRV IETLLMDTPS SYEAAMELFS PDQDMREAGA QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N.
Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human Uteroglobin. Anti-Human Uteroglobin-specific antibody was purified by affinity chromatography employing an immobilized Human Uteroglobin matrix.
Sandwich ELISA: To detect Human Uteroglobin by sandwich ELISA (using 100 µL/well), a concentration of 0.5-2.0 µg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human Uteroglobin (500-P330BT) as a detection antibody, allows the detection of at least 2000-4000 pg/mL of Recombinant Human Uteroglobin.
Western Blot: To detect Human Uteroglobin by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/mL. When used in conjunction with compatible secondary reagents, the detection limit for Recombinant Human Uteroglobin is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
Target Information
Uteroglobin, which is a member of the Secretoglobin superfamily and is also known as Clara cell phospholipid-binding protein, is a multifunctional protein that can exert anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. The small, non-glycosylated protein named for its high levels of expression in pre-implantation embryos, where it exhibits growth stimulatory effects, is produced and secreted by the non-ciliated, non-mucous Clara cells predominant in the epithelial surfaces of pulmonary airways, as well as other non-ciliated epithelia. Members of the Secretoglobin superfamily demonstrate a high level of structural conservation and are characterized as small, secretory homo- or heterodimers. In addition to sequestering pro-inflammatory mediators and carcinogens, Uteroglobin has been implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: blastokinin; CC10; CCPBP; clara cell phospholipid-binding protein; clara cells 10 kDa secretory protein; Club cell phospholipid-binding protein; Club cells 10 kDa secretory protein; Secretoglobin family 1A member 1; secretoglobin, family 1A, member 1 (uteroglobin); UP-1; Urinary protein 1; urine protein 1; Uteroglobin
Gene Aliases: CC10; CC16; CCPBP; CCSP; SCGB1A1; UGB; UP-1; UP1
UniProt ID: (Human) P11684
Entrez Gene ID: (Human) 7356
negative regulation of transcription from RNA polymerase II promoter
signal transduction
female pregnancy
embryo implantation
response to xenobiotic stimulus
response to ozone
response to lipopolysaccharide
negative regulation of interferon-gamma production
negative regulation of interleukin-13 production
negative regulation of interleukin-4 production
negative regulation of interleukin-5 production
response to silicon dioxide
response to cytokine
negative regulation of T cell proliferation
response to drug
negative regulation of catalytic activity
regulation of mRNA stability
regulation of inflammatory response
response to glucocorticoid
response to fibroblast growth factor
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