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PA1-765 detects vesicle associated membrane protein 1 (VAMP-1) from human, canine, mouse and rat tissues.
PA1-765 has been successfully used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects a 15 kDa protein representing VAMP-1 from rat brain whole protein extract.
The PA1-765 immunogen is a synthetic peptide corresponding to residues M(1) S A P A Q P P A E G T E G A A P G(18) C of rat VAMP-2. This immunizing peptide (Cat. # PEP-099) is available for use in neutralization and control experiments.
Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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