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Invitrogen
VANGL1 Polyclonal Antibody
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Product Details
PA5-101954
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human VANGL1(Accession Q8TAA9), corresponding to amino acid residues R352-A402.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total VANGL1.
Target Information
Vang-like 1 protein is a novel human homologue of Drosophila Van Gogh/Strabismus. The Vang-like 1 gene consists of at least 7 exons, and encodes a protein with four transmembrane domains and the C-terminal Ser/Thr-X-Val motif. Studies shows that the expression of the protein is significantly up-regulated in gastric cancer cell lines MKN28, MKN74, pancreatic cancer cell lines BxPC-3, PSN-1 and Hs766T. The protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa. The protein also serves as a diagnostic marker for hepatocellular carcinoma as well as a potential molecular target for development of novel therapeutic drugs. The pathological role of the protein has been identified in neural tube defects (NTD). Human Vang-like 1 gene maps to chromosome 1p11-p13.1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KAI1 C-terminal interacting tetraspanin; KAI1 COOH-terminal interacting tetraspanin; Loop-tail protein 2; Loop-tail protein 2 homolog; LPP2; strabismus; Strabismus 2; Van Gogh-like protein 1; vang, van gogh-like 1; vang-like 1 (van gogh, Drosophila); Vang-like protein 1
Gene Aliases: KITENIN; LPP2; STB2; Stbm; STBM2; VANGL1
UniProt ID: (Human) Q8TAA9, (Mouse) Q80Z96
Entrez Gene ID: (Human) 81839, (Mouse) 229658
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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