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Proteintech
VANGL2 Polyclonal Antibody
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Product Details
21492-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
VANGL2 Fusion Protein Ag15833 (268-322 aa encoded by BC103920)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IQRVAVWIL EKYYHDFPVY NPALLNLPKS VLAKKVSGFK VYSLGEENST NNSTGQ (268-322 aa encoded by BC103920)
Target Information
Van Gogh is an alternate name for the Drosophila strabismus protein. Van Gogh like-2 (VANGL2) is a 521 amino acidprotein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-disheveled tissue polarity pathway. It interacts through it's C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3 and is a potent tumor suppressor. It ispredominantly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process. It is expressed in a wide range of tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: loop tail associated protein; Loop-tail protein 1; Loop-tail protein 1 homolog; Loop-tail-associated protein; MGC119403; MGC119404; Strabismus 1; unnamed protein product; Van Gogh-like protein 2; vang; vang (van gogh)-like 2; vang-like 2 (van gogh, Drosophila); Vang-like protein 2; vangl2 {ECO:0000312|RGD:1309442}
Gene Aliases:
C530001F03Rik; KIAA1215; loop-tail; Lp; LPP1; LTAP; ska17; ska
UniProt ID: (Human) Q9ULK5, (Rat) P84889, (Mouse) Q91ZD4
Entrez Gene ID: (Human) 57216, (Rat) 289229, (Mouse) 93840
establishment of planar polarity
neural tube closure
hair follicle development
heart looping
membranous septum morphogenesis
muscular septum morphogenesis
Rho protein signal transduction
anterior/posterior pattern specification
heparan sulfate proteoglycan biosynthetic process
convergent extension involved in neural plate elongation
regulation of Wnt signaling pathway
glomerulus development
regulation of actin cytoskeleton organization
somatic stem cell population maintenance
non-canonical Wnt signaling pathway
cell migration involved in kidney development
post-anal tail morphogenesis
dopaminergic neuron axon guidance
serotonergic neuron axon guidance
wound healing
apical protein localization
establishment or maintenance of epithelial cell apical/basal polarity
somatic stem cell division
establishment of body hair planar orientation
digestive tract morphogenesis
convergent extension involved in axis elongation
convergent extension involved in organogenesis
Wnt signaling pathway, planar cell polarity pathway
inner ear receptor cell development
inner ear receptor stereocilium organization
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
lateral sprouting involved in lung morphogenesis
kidney morphogenesis
cochlea development
cochlea morphogenesis
regulation of establishment of planar polarity
establishment of planar polarity involved in neural tube closure
non-motile cilium assembly
regulation of synapse pruning
planar cell polarity pathway involved in axis elongation
biological_process
nonmotile primary cilium assembly
positive regulation of JUN kinase activity
planar cell polarity pathway involved in heart morphogenesis
planar cell polarity pathway involved in neural tube closure
patterning of blood vessels
outflow tract septum morphogenesis
epicardial cell to mesenchymal cell transition
multicellular organism development
cardiac vascular smooth muscle cell differentiation
establishment of epithelial cell polarity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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