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Invitrogen
VASH1 Polyclonal Antibody
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Product Details
PA5-21148
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 19 amino acid peptide near the carboxy terminus of human VASH1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human brain tissue lysate.
PA5-21148 can be used with blocking peptide PEP-1262.
Target Information
VASH1 is a protein that possesses actin binding activity and metallocarboxypeptidase activity. It is involved in several processes including negative regulation of angiogenesis, negative regulation of blood vessel endothelial cell migration, and proteolysis. VASH1 acts upstream of or within processes such as negative regulation of endothelial cell migration, negative regulation of endothelial cell proliferation, and negative regulation of lymphangiogenesis. It is located in the apical part of the cell, endoplasmic reticulum, and extracellular space. VASH1 is implicated in liver cirrhosis and portal hypertension, and is a biomarker of liver cirrhosis. Diseases associated with VASH1 include Portal Hypertension and Myasthenic Syndrome, Congenital, 14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: TTCP 1; Tubulin carboxypeptidase 1; Tubulinyl-Tyr carboxypeptidase 1; Tyrosine carboxypeptidase 1; unnamed protein product; vasohibin 1; Vasohibin-1
Gene Aliases: AI834978; D930046M13Rik; G630009D10Rik; KIAA1036; RGD1564082; TTCP 1; VASH; VASH1
UniProt ID: (Human) Q7L8A9, (Mouse) Q8C1W1
Entrez Gene ID: (Human) 22846, (Mouse) 238328, (Rat) 503052
angiogenesis
negative regulation of endothelial cell proliferation
proteolysis
response to wounding
negative regulation of angiogenesis
negative regulation of blood vessel endothelial cell migration
regulation of angiogenesis
regulation of cell cycle
placenta blood vessel development
labyrinthine layer blood vessel development
negative regulation of lymphangiogenesis
regulation of cellular senescence
cell cycle
cell cycle arrest
negative regulation of endothelial cell migration
positive regulation of gene expression
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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