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Product Details
PA5-51434
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human VASH1. Recombinant protein control fragment (Product #RP-88864).
Conjugate
Form
Liquid
Concentration
0.09 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2649394
Product Specific Information
Immunogen sequence: GALGMSRRED LMYKPPAFRT LSELVLDFEA AYGRCWHVLK KVKLGQSVSH DPHSVEQIEW KHSVLDVERL GRDDFRKELE RHARDMRLKI GKGTGPPSPT KDRKKDVSSP QRAQSSPHRR NSRSERRPSG DKKTSEPKAM PD
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Target Information
VASH1 is a protein that possesses actin binding activity and metallocarboxypeptidase activity. It is involved in several processes including negative regulation of angiogenesis, negative regulation of blood vessel endothelial cell migration, and proteolysis. VASH1 acts upstream of or within processes such as negative regulation of endothelial cell migration, negative regulation of endothelial cell proliferation, and negative regulation of lymphangiogenesis. It is located in the apical part of the cell, endoplasmic reticulum, and extracellular space. VASH1 is implicated in liver cirrhosis and portal hypertension, and is a biomarker of liver cirrhosis. Diseases associated with VASH1 include Portal Hypertension and Myasthenic Syndrome, Congenital, 14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: TTCP 1; Tubulin carboxypeptidase 1; Tubulinyl-Tyr carboxypeptidase 1; Tyrosine carboxypeptidase 1; Vasohibin-1
Gene Aliases: KIAA1036; VASH; VASH1
UniProt ID: (Human) Q7L8A9
Entrez Gene ID: (Human) 22846
angiogenesis
negative regulation of endothelial cell proliferation
cell cycle arrest
response to wounding
negative regulation of endothelial cell migration
negative regulation of angiogenesis
negative regulation of blood vessel endothelial cell migration
negative regulation of lymphangiogenesis
regulation of cellular senescence
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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