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Invitrogen
VAV1 Polyclonal Antibody
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Product Details
PA5-21495
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human VAV1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.49 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: Jurkat, NCI-H929, BCL-1.
Predicted reactivity: Mouse (92%), Rat (92%), Pig (96%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: oncogene vav; p95vav; Proto-oncogene vav; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav oncogene; vav proto-oncogene
Gene Aliases: VAV; vav-T; VAV1
UniProt ID: (Human) P15498, (Mouse) P27870
Entrez Gene ID: (Human) 7409, (Mouse) 22324
regulation of transcription, DNA-templated
immune response
G-protein coupled receptor signaling pathway
integrin-mediated signaling pathway
small GTPase mediated signal transduction
regulation of cell size
regulation of phosphatidylinositol 3-kinase signaling
platelet activation
T cell differentiation
neutrophil chemotaxis
T cell costimulation
regulation of Rho protein signal transduction
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of apoptotic process
regulation of GTPase activity
positive regulation of GTPase activity
positive regulation of natural killer cell mediated cytotoxicity
phosphatidylinositol phosphorylation
vascular endothelial growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
regulation of small GTPase mediated signal transduction
reactive oxygen species metabolic process
phagocytosis
intracellular signal transduction
T cell activation
positive regulation of cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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