This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Recommended positive controls: Jurkat, NCI-H929, BCL-1.
Predicted reactivity: Mouse (92%), Rat (92%), Pig (96%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: oncogene vav; p95vav; Proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav oncogene; vav proto-oncogene
Gene Aliases: VAV; vav-T; VAV1