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Invitrogen
VAV3 Polyclonal Antibody
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Product Details
PA5-90428
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 560-680 of human VAV3 (NP_0061044)
Conjugate
Form
Liquid
Concentration
1.8 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DNCGRVNSGE QGTLKLPEKR TNGLRRTPKQ VDPGLPKMQV IRNYSGTPPP ALHEGPPLQL QAGDTVELLK GDAHSLFWQG RNLASGEVGF FPSDAVKPCP CVPKPVDYSC QPWYAGAMER L; Positive Samples: Jurkat, Mouse brain, Mouse lung, Mouse spleen
Target Information
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ40431; Guanine nucleotide exchange factor VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3
Gene Aliases: A530094I06Rik; AA986410; Idd18.1; VAV3
UniProt ID: (Human) Q9UKW4, (Mouse) Q9R0C8
Entrez Gene ID: (Human) 10451, (Mouse) 57257
angiogenesis
vesicle fusion
cellular response to DNA damage stimulus
integrin-mediated signaling pathway
small GTPase mediated signal transduction
regulation of cell size
positive regulation of signal transduction
lamellipodium assembly
platelet activation
neutrophil chemotaxis
positive regulation of B cell proliferation
regulation of Rho protein signal transduction
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
response to drug
positive regulation of apoptotic process
regulation of GTPase activity
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of cell adhesion
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
B cell receptor signaling pathway
regulation of small GTPase mediated signal transduction
cell migration
cell projection assembly
intracellular signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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