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Invitrogen

VCP Polyclonal Antibody

View all (31) VCP antibodies
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Product Details

Applications
Tested Dilution
Publications
Immunocytochemistry (ICC)
1:50-1:200
-
Immunofluorescence (IF)
1:50-1:200
-
Immunohistochemistry (Paraffin) (IHC (P))
1:50-1:200
-
Western Blot (WB)
1:500-1:2000
-
Product Specifications
Species Reactivity
Human, Mouse, Rat
Host / Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 647-806 of human VCP
Conjugate
Unconjugated
Form
liquid
Concentration
1.77 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2805409

Product Specific Information

Immunogen sequence: LPDEKSRVAI LKANLRKSPV AKDVDLEFLA KMTNGFSGAD LTEICQRACK LAIRESIESE IRRERERQTN PSAMEVEEDD PVPEIRRDHF EEAMRFARRS VSDNDIRKYE MFAQTLQQSR GFGSFRFPSG NQGGAGPSQG SGGGTGGSVY TEDNDDDLYG; Positive Samples: U-251MG, 293T, HeLa, NIH/3T3, A-549, SW480, Mouse kidney, Rat brain; Cellular Location: Cytoplasm, Endoplasmic reticulum, Nucleus, cytosol

Target Information

The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 15S Mg(2+)-ATPase p97 subunit; AAA ATPase p97; epididymis luminal protein 220; epididymis secretory protein Li 70; homolog of yeast cdc48; Inv protein; or HEL-S-70; p97 atpase; TER ATPase; Transitional endoplasmic reticulum ATPase; Valosin-containing protein; VCP; yeast Cdc48p homolog

Gene Aliases: 3110001E05; ALS14; CDC48; CMT2Y; HEL-220; HEL-S-70; IBMPFD; IBMPFD1; p97; p97/VCP; TERA; VCP

UniProt ID: (Human) P55072, (Mouse) Q01853, (Rat) P46462

Entrez Gene ID: (Human) 7415, (Mouse) 269523, (Rat) 116643

Function(s)
DNA repair double-strand break repair ubiquitin-dependent protein catabolic process transport ER to Golgi vesicle-mediated transport activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus protein ubiquitination protein N-linked glycosylation via asparagine viral genome replication translesion synthesis ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol positive regulation of protein complex assembly positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein hexamerization positive regulation of protein catabolic process protein homooligomerization aggresome assembly ER-associated misfolded protein catabolic process positive regulation of protein K63-linked deubiquitination positive regulation of Lys63-specific deubiquitinase activity NADH metabolic process autophagy positive regulation of mitochondrial membrane potential endoplasmic reticulum unfolded protein response ERAD pathway regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process establishment of protein localization ATP metabolic process error-free translesion synthesis flavin adenine dinucleotide catabolic process autophagosome maturation regulation of aerobic respiration positive regulation of oxidative phosphorylation positive regulation of ubiquitin-specific protease activity positive regulation of ATP biosynthetic process
Process(es)
protein binding ATP binding lipid binding ATPase activity protein phosphatase binding protein domain specific binding polyubiquitin binding ubiquitin protein ligase binding deubiquitinase activator activity K48-linked polyubiquitin binding MHC class I protein binding identical protein binding ADP binding ubiquitin-like protein ligase binding poly(A) RNA binding BAT3 complex binding ubiquitin-specific protease binding nucleotide binding receptor binding hydrolase activity protein complex binding

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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