PA1-954A detects voltage-dependent anion channel (VDAC) from human, non-human primates, mouse, and rat samples.
PA1-954A has been successfully used in IF/ICC, IHC (P) and Western blot procedures. By Western blot, this antibody detects a single, prominent ~31 kDa band representing VDAC from rat heart extract.
PA1-954A immunizing peptide corresponds to the C-terminal amino acid residues 185-197 of human VDAC3. This sequence is completely conserved between isoforms 1, 2 and 3 of human VDAC and PA1-954A detects endogenous levels of total VDAC. PA1-954A immunizing peptide (Cat. # PEP-082) is available for use in neutralization and control experiments.
The Voltage-Dependent Anion Channel (VDAC or mitochondrial Porin) is an outer membrane mitochondrial protein. The VDAC protein is thought to form the major pores through which adenine nucleotides are transferred through the outer mitochondrial membrane.
VDAC has also been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, adenine nucleotide translocator (ANT), and cyclophilin D (CypD), is thought to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Mitochondrial Porin; mVDAC1; mVDAC5; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM; rVDAC1; VDAC-1; VDAC-5; Voltage-Dependent Anion Channel; Voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 5
Gene Aliases: AL033343; PORIN; VDAC; VDAC-1; VDAC1; Vdac5