PA1-954A detects voltage-dependent anion channel (VDAC) from human, non-human primates, mouse, and rat samples.
PA1-954A has been successfully used in IF/ICC, IHC (P) and Western blot procedures. By Western blot, this antibody detects a single, prominent ~31 kDa band representing VDAC from rat heart extract.
PA1-954A immunizing peptide corresponds to the C-terminal amino acid residues 185-197 of human VDAC3. This sequence is completely conserved between isoforms 1, 2 and 3 of human VDAC and PA1-954A detects endogenous levels of total VDAC. PA1-954A immunizing peptide (Cat. # PEP-082) is available for use in neutralization and control experiments.
Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC constitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hVDAC1; MGC111064; Mitochondrial Porin; mVDAC1; mVDAC5; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM; PORIN-31-HL; rVDAC1; VD; VDAC-1; VDAC-5; Voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 5
Gene Aliases: AL033343; PORIN; VDAC; VDAC-1; VDAC1; Vdac5