Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
Porin belongs to the eukaryotic mitochondrial porin family of voltage dependent anion channels which allow the transport of adenine nucleotides and other metabolites throught the outer mitochondrial membrane. The conformation of the protein is regulated by membrane potential, which affects its divalent metal ion selectivity. Porin is also involved in mitochondrial apoptosis, forming permeability transition pore complexes (PTPC) in association with adenine nucleotide transporter, and cyclophilin D, leading to release of apoptogenic factors that activate caspases and initiate cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MGC111064; Outer mitochondrial membrane protein porin; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; PORIN; Porin 31HL; Porin 31HM; PORIN-31-HL; VD; VDAC-1; Voltage-dependent anion-selective channel protein 1
Gene Aliases: PORIN; VDAC; VDAC-1; VDAC1
UniProt ID: (Human) P21796
Entrez Gene ID: (Human) 7416