This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
Predicted to react with dog, mouse and rat based on sequence homology.
In Western blot, this antibody detects a band at ~40-45kDa in human brain cell lysate. A minimum incubation time of 1 hour is recommended with this antibody.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1,25-dihydroxyvitamin D3 receptor; NR1I1; Nuclear receptor subfamily 1 group I member 1; protein phosphatase 1, regulatory subunit 163; VDR; vitamin D nuclear receptor variant 1; vitamin D receptor; Vitamin D3 receptor
Gene Aliases: NR1I1; PPP1R163; VDR
UniProt ID: (Human) P11473
Entrez Gene ID: (Human) 7421