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Invitrogen

VEGF Receptor 1/2 Polyclonal Antibody

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VEGF Receptor 1/2 Polyclonal Antibody

Product Details

PA1-16612

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:250-1:500
-

Immunocytochemistry (ICC/IF)

1:500
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide made to an internal region of the mouse VEGF Receptor 1 protein (between residues 800-900).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_568765

Product Specific Information

The target sequence has 100% sequence homology with mouse and rat.

Target Information

Receptors for VEGF, VEGFB and PGF have a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: fetal liver kinase 1; fetal liver kinase-1; FLK-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); fms related tyrosine kinase 1; FMS-like tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); kinase domain; kinase insert domain protein receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); protein kinase; protein-tyrosine kinase receptor Flk-1; sFLT1-14; soluble VEGF receptor; soluble VEGFR 1; soluble VEGFR2; sVEGFR 1; tyrosine kinase growth factor receptor; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; unnamed protein product; vascular endothelial growth factor receptor 1-like; vascular endothelial growth factor receptor/VEGF receptor/cell surface tyrosine kinase; vascular endothelial growth factor/vascular permeability factor receptor; vascular permeability factor receptor; VEGF R1; VEGFR 1; VEGFR-2; tyrosine kinase; VEGFR1 variant; VEGFR; tyrosine kinase

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Gene Aliases: CD309; FLK1; FLT; FLT-1; VEGFR; VEGFR-1; Vegfr-2; VEGFR1; VEGFR2

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UniProt ID: (Human) P17948, (Human) P35968, (Rat) O08775

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Entrez Gene ID: (Human) 2321, (Rat) 54251, (Human) 3791, (Rat) 25589

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity protein binding ATP binding growth factor binding placental growth factor-activated receptor activity identical protein binding integrin binding coreceptor activity vascular endothelial growth factor binding cadherin binding Hsp90 protein binding
Process(es)
sprouting angiogenesis monocyte chemotaxis transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation cell migration peptidyl-tyrosine phosphorylation positive regulation of cell migration cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-1 signaling pathway vascular endothelial growth factor signaling pathway regulation of cell proliferation positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway blood vessel morphogenesis embryonic morphogenesis positive regulation of developmental process positive regulation of protein kinase B signaling negative regulation of vascular endothelial cell proliferation hyaloid vascular plexus regression angiogenesis patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation vasculature development endocardium development endothelium development regulation of cell shape positive regulation of endothelial cell migration negative regulation of gene expression positive regulation of macroautophagy positive regulation of BMP signaling pathway embryonic hemopoiesis vascular endothelial growth factor receptor-2 signaling pathway negative regulation of apoptotic process regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration endothelial cell differentiation positive regulation of positive chemotaxis positive regulation of focal adhesion assembly positive regulation of mitochondrial depolarization epithelial tube morphogenesis vascular wound healing positive regulation of ERK1 and ERK2 cascade semaphorin-plexin signaling pathway positive regulation of cell migration involved in sprouting angiogenesis positive regulation of mitochondrial fission positive regulation of nitric oxide-cGMP mediated signal transduction cellular response to hydrogen sulfide negative regulation of endothelial cell apoptotic process positive regulation of endothelial cell chemotaxis positive regulation of vasculogenesis response to hypoxia protein phosphorylation regulation of smooth muscle contraction female pregnancy response to activity intracellular receptor signaling pathway response to estradiol positive regulation of vascular permeability response to ethanol positive regulation of fibroblast proliferation post-embryonic camera-type eye morphogenesis positive regulation of smooth muscle cell proliferation positive regulation of glial cell proliferation cellular response to hypoxia liver regeneration positive regulation of hematopoietic progenitor cell differentiation negative regulation of sprouting angiogenesis negative regulation of vascular endothelial growth factor production ovarian follicle development regulation of endothelial cell proliferation lymph vessel development positive regulation of mesenchymal cell proliferation negative regulation of systemic arterial blood pressure endochondral bone growth positive regulation of cytosolic calcium ion concentration gonad development male gonad development response to xenobiotic stimulus positive regulation of signal transduction hemopoiesis lung development positive regulation of TOR signaling vasodilation surfactant homeostasis cell fate commitment positive regulation of long-term neuronal synaptic plasticity lung alveolus development cell maturation response to axon injury branching morphogenesis of an epithelial tube neuron projection morphogenesis positive regulation of epithelial cell proliferation positive regulation of neurogenesis positive regulation of calcium-mediated signaling calcium ion homeostasis endothelial tube morphogenesis response to oxygen levels regulation of hematopoietic progenitor cell differentiation regulation of bone development
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