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Invitrogen
VEGF Receptor 1 Polyclonal Antibody
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Product Details
PA5-32408
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from C-terminus of human FLT-1.
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
200 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.6, with 1% BSA
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is placenta or angiosarcoma.
Target Information
FLT1 (VEGFR1) is a receptor tyrosine kinase which plays a critical role in angiogenesis. Active angiogenesis has been found to play important role in many pathological and physiological processes, such as tumor progression, diabetic retinopathy, rheumatoid arthritis and wound healing. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLT; FLT-1; fms related tyrosine kinase 1; Fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); i21; kinase domain; protein kinase; sFLT1-14; soluble VEGF receptor; soluble VEGFR 1; sVEGFR 1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; unnamed protein product; Vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor/VEGF receptor/cell surface tyrosine kinase; Vascular permeability factor receptor; VEGF R1; VEGFR-1; VEGFR1 variant; VEGFR; tyrosine kinase
Gene Aliases: FLT; FLT-1; FLT1; FRT; VEGFR-1; VEGFR1
UniProt ID: (Human) P17948
Entrez Gene ID: (Human) 2321
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity
protein binding
ATP binding
kinase activity
transferase activity
growth factor binding
placental growth factor-activated receptor activity
angiogenesis
sprouting angiogenesis
monocyte chemotaxis
chemotaxis
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
cell migration
peptidyl-tyrosine phosphorylation
cell differentiation
positive regulation of cell migration
cellular response to vascular endothelial growth factor stimulus
vascular endothelial growth factor receptor-1 signaling pathway
vascular endothelial growth factor signaling pathway
regulation of cell proliferation
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of angiogenesis
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
blood vessel morphogenesis
embryonic morphogenesis
positive regulation of developmental process
positive regulation of protein kinase B signaling
negative regulation of vascular endothelial cell proliferation
hyaloid vascular plexus regression
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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