|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the C-terminal region of the soluble form of the human VEGF Receptor-1 (sVEGFR-1, sFlt-1) protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Flt-1/vascular endothelial growth factor receptor 1 (VEGFR1), a cell membrane receptor kinase, is a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis. It contains seven immunoglobulin like sequences in the extracellular domain and exhibits sequence similarity to Flk-1 and Flt-4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.
36-1100 was used in western blot to elucidate the link between CMT2D neuropathy and glycyl-tRNA synthetase
|He W,Bai G,Zhou H,Wei N,White NM,Lauer J,Liu H,Shi Y,Dumitru CD,Lettieri K,Shubayev V,Jordanova A,Guergueltcheva V,Griffin PR,Burgess RW,Pfaff SL,Yang XL||Nature (526:710)||2015|
|Human||Not Cited||Expression of receptors for VEGFs on normal human thyroid follicular cells and their role in follicle formation.||Susarla R,Gonzalez AM,Watkinson JC,Eggo MC||Journal of cellular physiology (227:1992)||2012|
|Not Applicable||Not Cited||
Novel soluble Flt-1 isoforms in plasma and cultured placental explants from normotensive pregnant and preeclamptic women.
36-1100 was used in western blot to study the contribution of sFlt-1 to preeclampsia
|Rajakumar A,Powers RW,Hubel CA,Shibata E,von Versen-Höynck F,Plymire D,Jeyabalan A||Placenta (30:25)||2009|
Role of VEGF-A and its receptors in sporadic and MEN2-associated pheochromocytoma.
36-1100 was used in immunohistochemistry - paraffin section to study the involvement of VEGF-A and its receptors in sporadic and MEN2-associated pheochromocytoma.
|Ferreira CV,Siqueira DR,Romitti M,Ceolin L,Brasil BA,Meurer L,Capp C,Maia AL||International journal of molecular sciences (15:5323)||2014|
||Expression of receptors for VEGFs on normal human thyroid follicular cells and their role in follicle formation.||Susarla R,Gonzalez AM,Watkinson JC,Eggo MC||Journal of cellular physiology (227:1992)||2012|
Local retention versus systemic release of soluble VEGF receptor-1 are mediated by heparin-binding and regulated by heparanase.
36-1100 was used in immunohistochemistry to discuss pericellular retention of sVEGF-R1.
|Sela S,Natanson-Yaron S,Zcharia E,Vlodavsky I,Yagel S,Keshet E||Circulation research (108:1063)||2011|