Invitrogen

VEGF Receptor 2 Polyclonal Antibody

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View all (77) FLK1 (VEGF Receptor 2) antibodies

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VEGF Receptor 2 Polyclonal Antibody

Product Details

PA1-16613

Applications
Tested Dilution
Publications

Western Blot (WB)

1:250-1:1,000
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Affinity Purification (AP)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

C. elegans, Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide made to an internal region of the mouse VEGF Receptor 2 protein (between residues 1200-1300).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

TBS

Contains

0.05% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_568766

Product Specific Information

The target sequence has 100% sequence homology with mouse and rat.

Suggested positive control: HUVEC lysate, antigen standard for KDR (transient overexpression lysate).

Target Information

KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD309; CD309 antigen; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; KDR; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Kinase NYK; Protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; soluble VEGFR2; tyrosine kinase growth factor receptor; Vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor-2; VEGFR-2

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Gene Aliases: 6130401C07; CD309; Flk-1; FLK1; KDR; Krd-1; Ly73; sVEGFR-2; VEGFR; VEGFR-2; VEGFR2

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UniProt ID: (Human) P35968, (Mouse) P35918

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Entrez Gene ID: (Human) 3791, (Mouse) 16542

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Function(s)
protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity integrin binding protein binding ATP binding growth factor binding Hsp90 protein binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups vascular endothelial growth factor binding transmembrane signal receptor
Process(es)
angiogenesis vasculogenesis positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation cell migration involved in sprouting angiogenesis endothelium development transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation regulation of cell shape positive regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase signaling viral process positive regulation of macroautophagy peptidyl-tyrosine phosphorylation signal transduction by protein phosphorylation extracellular matrix organization positive regulation of cell migration embryonic hemopoiesis calcium-mediated signaling using intracellular calcium source cellular response to vascular endothelial growth factor stimulus positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway peptidyl-tyrosine autophosphorylation negative regulation of apoptotic process positive regulation of MAPK cascade positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway positive regulation of positive chemotaxis positive regulation of nitric-oxide synthase biosynthetic process positive regulation of focal adhesion assembly positive regulation of mitochondrial depolarization positive regulation of ERK1 and ERK2 cascade positive regulation of mitochondrial fission negative regulation of endothelial cell apoptotic process positive regulation of vasculogenesis ovarian follicle development response to hypoxia regulation of endothelial cell proliferation lymph vessel development positive regulation of mesenchymal cell proliferation endocardium development endochondral bone growth protein phosphorylation positive regulation of cytosolic calcium ion concentration multicellular organism development male gonad development phosphorylation cell migration hemopoiesis cell differentiation lung development positive regulation of BMP signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of TOR signaling vascular endothelial growth factor signaling pathway response to drug surfactant homeostasis negative regulation of neuron apoptotic process cell fate commitment endothelial cell differentiation regulation of endothelial cell differentiation positive regulation of vasodilation positive regulation of long-term neuronal synaptic plasticity lung alveolus development cell maturation branching morphogenesis of an epithelial tube neuron projection morphogenesis positive regulation of epithelial cell proliferation positive regulation of calcium-mediated signaling calcium ion homeostasis blood vessel endothelial cell differentiation regulation of hematopoietic progenitor cell differentiation
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