PA5-16871 targets Flt-4 in immunohistochemistry (paraffin), immunoprecipitation, and Western blot applications and shows reactivity with human, mouse, and rat samples.
The PA5-16871 immunogen is a synthetic peptide derived from C-terminus of human Flt-4.
Three cell membrane receptor tyrosine kinases, Flt (also designated VEGF-R1), Flk-1 (also designated VEGF-R2) and Flt-4 (also designated VEGF-R3), putatively involved in the growth of endothelial cells, are characterized by the presence of seven immuno-globulin-like sequences in their extracellular domain. On the basis of structural similarity to Flt and Flk-1, it has been speculated that Flt-4 might represent a third receptor for eother VEGF or a VEGF-related ligand.
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Protein Aliases: chylous ascites; FLT-4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; receptor protein tyrosine kinase; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; Tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGFR-3
Gene Aliases: AI323512; Chy; FLT-4; FLT4; FLT41; LMPH1A; PCL; VEGFR-3; VEGFR3