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Invitrogen
VEGFB Polyclonal Antibody
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FIGURE: 1 / 1
VEGFB Antibody (PA5-86263) in WB
Western blot analysis of VEGFB in Lane 1: K562 whole cell lysate (40 µg), Lane 2: A549 whole cell lysate (40 µg), Lane 3: Heart tissue lysate of rat (40 µg), Lane 4: Heart tissue lysate of mouse (40 µg). Sample was incubated with VEGFB polyclonal antibody (Product # PA5-86263) using a 1:500 dilution.
Product Details
PA5-86263
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 100-150 of Human VEGFB.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. VEGFB has structural similarities to VEGF and PIGF and is frequently co-expressed with VEGF. There are two alternatively spliced isoforms of VEGFB: VEGFB 167 and VEGFB 186. VEGFB 167, a highly basic heparin-binding protein, remains with the cell or extracellular matrix whereas, VEGFB 186 is readily secreted. VEGFB stimulates endothelial cell proliferation. VEGFB binds to the tyrosine kinase receptor VEGFR1 (flt1) and does not bind to VEGFR2. Vascular Endothelial Growth Factor B is widely expressed but is most abundant in heart, skeletal muscle, and pancreas. It has been suggested that VEGFB expression in human primary breast cancers is associated with lymph node metastasis. The genes that encode VEGFB have been mapped to chromosome 11q13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF
Gene Aliases: VEGF-B; VEGFB; VEGFL; VRF
UniProt ID: (Human) P49765, (Rat) O35485, (Mouse) P49766
Entrez Gene ID: (Human) 7423, (Rat) 89811, (Mouse) 22340
vascular endothelial growth factor receptor binding
protein binding
growth factor activity
heparin binding
chemoattractant activity
identical protein binding
vascular endothelial growth factor receptor 1 binding
receptor agonist activity
molecular_function
protein homodimerization activity
protein heterodimerization activity
growth factor
response to hypoxia
positive regulation of endothelial cell proliferation
sprouting angiogenesis
protein O-linked glycosylation
heart development
positive regulation of cell proliferation
negative regulation of gene expression
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of vascular wound healing
vascular endothelial growth factor signaling pathway
negative regulation of apoptotic process
positive regulation of vascular permeability
negative regulation of neuron apoptotic process
vascular endothelial growth factor receptor signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
induction of positive chemotaxis
positive regulation of cell division
positive regulation of protein kinase B signaling
cardiac muscle contraction
positive regulation of mast cell chemotaxis
coronary vasculature development
positive regulation of ERK1 and ERK2 cascade
angiogenesis
response to drug
multicellular organism development
cell differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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