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Proteintech
VHL Polyclonal Antibody
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Product Details
24756-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
VHL Fusion Protein Ag21447 (90-172 aa encoded by BC058831)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NFDGEPQPY PTLPPGTGRR IYSYRVYTLK ERCLQVVRSL VKPENYRRLD IVRSLYEDLE DHPNVQKDLE RLTQERIAHQ RMGD (90-172 aa encoded by BC058831)
Target Information
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: elongin binding protein; Protein G7; pVHL; unnamed protein product; VHL19; VHLp18(MEA); Von Hippel Lindau; von hippel-lindau; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Gene Aliases: HRCA1; pVHL; RCA1; VHL; VHL1
UniProt ID: (Human) P40337
Entrez Gene ID: (Human) 7428
obsolete transcription elongation regulator activity
ubiquitin-protein transferase activity
protein binding
enzyme binding
binding, bridging
protein serine/threonine kinase binding
DNA-binding transcription factor binding
protein binding, bridging involved in substrate recognition for ubiquitination
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
response to hypoxia
regulation of transcription, DNA-templated
proteolysis
negative regulation of cell proliferation
negative regulation of signal transduction
regulation of gene expression
negative regulation of autophagy
negative regulation of macromolecule biosynthetic process
negative regulation of gene expression
protein ubiquitination
negative regulation of transcription elongation from RNA polymerase II promoter
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of cell differentiation
positive regulation of transcription, DNA-templated
negative regulation of JAK-STAT cascade
protein stabilization
cellular response to hypoxia
regulation of cellular response to hypoxia
negative regulation of TORC1 signaling
amyloid fibril formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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