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Invitrogen

VHL Polyclonal Antibody

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View all (19) VHL antibodies

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VHL Polyclonal Antibody

Product Details

PA5-87428

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.21 mg/mL

Amount

121 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804139

Product Specific Information

Positive Samples: HeLa, Mouse brain, Rat brain; Cellular Location: Cytoplasm, Membrane, Nucleus, Nucleus, Peripheral membrane protein

Immunogen sequence: RSLVKPENYR RLDIVRSLYE

Target Information

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: elongin binding protein; Protein G7; pVHL; unnamed protein product; VHL19; VHLp18(MEA); Von Hippel Lindau; von hippel-lindau; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome homolog; von Hippel-Lindau syndrome protein homolog; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

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Gene Aliases: HRCA1; pVHL; RCA1; VHL; VHL1; Vhlh

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UniProt ID: (Human) P40337, (Mouse) P40338, (Rat) Q64259

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Entrez Gene ID: (Human) 7428, (Mouse) 22346, (Rat) 24874

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Function(s)
obsolete transcription elongation regulator activity ubiquitin-protein transferase activity protein binding enzyme binding binding, bridging protein serine/threonine kinase binding DNA-binding transcription factor binding protein binding, bridging involved in substrate recognition for ubiquitination transcription factor binding protein complex binding ubiquitin protein ligase activity ubiquitin-protein ligase
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis response to hypoxia regulation of transcription, DNA-templated proteolysis negative regulation of cell proliferation negative regulation of signal transduction regulation of gene expression negative regulation of autophagy negative regulation of macromolecule biosynthetic process negative regulation of gene expression protein ubiquitination negative regulation of transcription elongation from RNA polymerase II promoter negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of cell differentiation positive regulation of transcription, DNA-templated negative regulation of JAK-STAT cascade protein stabilization cellular response to hypoxia regulation of cellular response to hypoxia negative regulation of TORC1 signaling amyloid fibril formation angiogenesis type B pancreatic cell differentiation pancreatic A cell differentiation NLS-bearing protein import into nucleus proteasomal protein catabolic process protein transport protein catabolic process neuron differentiation extracellular matrix organization regulation of catecholamine metabolic process blood vessel endothelial cell migration negative regulation of endothelial cell differentiation protein heterooligomerization negative regulation of transcription from RNA polymerase II promoter in response to hypoxia regulation of thymocyte apoptotic process negative regulation of thymocyte apoptotic process negative regulation of hypoxia-inducible factor-1alpha signaling pathway regulation of apoptotic signaling pathway response to ethanol
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