Immunogen sequence: ARDRDYRALC DVGTAISCSR VFSSRW
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form which is essential for blood clotting. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is VKORC1 that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance.
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Protein Aliases: 3-epoxide reductase subunit 1; EDTP308; IMAGE3455200; MST134; MST576; phylloquinone epoxide reductase; vitamin K dependent clotting factors deficiency 2; Vitamin K epoxide reductase complex subunit 1; vitamin K epoxide reductase complex, subunit 1; vitamin K1 2; Vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive); VKCFD2; VKOR
Gene Aliases: EDTP308; MST134; MST576; MSTP134; MSTP576; UNQ308/PRO351; VKCFD2; VKOR; VKORC1
UniProt ID: (Human) Q9BQB6
Entrez Gene ID: (Human) 79001
Molecular Function: oxidoreductase