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VNN1 Polyclonal Antibody
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Product Details
BS-10314R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human VNN1, amino acids 151-250.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Hematopoietic precursor cells migrate to the thymus, where they differentiate into mature T lymphocytes. GPI-anchored vanin-1 protein regulates the late adhesion steps of thymus homing of bone marrow precursor cells. Vanin-1 is ubiquitously expressed as a pantetheinase enzyme and catalyzes the hydrolysis of pantetheine for vitamin B5 recycling. The hydrolytic activity of vanin-1 generates the potent antioxidant cysteamine as a metabolite. As a membrane bound pantetheinase, vanin-1 provides the main source of cysteamine under normal physiological conditions. In mice, vanin-1 is expressed specifically in male Sertoli cells of the developing testis, where it aids in cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Pantetheinase; Pantetheine hydrolase; Tiff66; unnamed protein product; Vanin-1; Vanin1; vannin 1; Vascular non-inflammatory molecule 1
Gene Aliases: HDLCQ8; Tiff66; V-1; VNN1
UniProt ID: (Human) O95497, (Mouse) Q9Z0K8
Entrez Gene ID: (Human) 8876, (Mouse) 22361, (Rat) 29142
acute inflammatory response
chronic inflammatory response
inflammatory response
response to oxidative stress
coenzyme A catabolic process
pantothenate metabolic process
positive regulation of T cell differentiation in thymus
innate immune response
cell-cell adhesion
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
nitrogen compound metabolic process
single organismal cell-cell adhesion
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
biological_process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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