Immunogen sequence: YEGLIDEIY GIQNSYVKLP PEKFAPKKQG DGGKDLPTEA KKLQLNSAEE LYAEIRDKNF NAVGSVLSKK AKIISAAFEE RHNAKTVGEI KQFVSQLPHM QAARGSLANH TSIAELIKDV TTSEDFFDKL TVEQEFMSGI DTDKVNNYIE DCIAQKHSLI KVLRLVCLQS VCNSGLKQKV LDYYKREILQ TYGYEHILTL HNLEKAGLLK PQTGGRNNYP TIRKTLRLWM DDVNEQNPTD ISYVYSGYAP LSVRLAQLLS RPGWRSIEEV LRILPGPHFE ERQPLPTGLQ KKRQPGENRV TLIFFLGGVT FAEIAALRFL SQLEDGGTEY VIATTKLMNG TSWIEALMEK PF (246-596 aa encoded by BC016617)
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and it encodes a protein similar to the yeast class C Vps33 protein. The mammalian class C VPS proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
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Protein Aliases: buff; hVPS33A; vacuolar protein sorting 33 homolog A; vacuolar protein sorting 33A; vacuolar protein sorting protein 33a; Vacuolar protein sorting-associated protein 33A; vacuolar sorting protein 33a; VPS33A CORVET/HOPS core subunit
Gene Aliases: 3830421M04Rik; AI503300; AW048546; AW554476; Bf; Buff; r-Vps33a; VPS33A
Molecular Function: membrane trafficking regulatory protein