Peptide sequence: TYEGLIDEIY GIQNSYVKLP PEKFAPKKQG DGGKDLPTEA KKLQLNSAEE
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 81%; Rabbit: 93%; Rat: 93%; Zebrafish: 86%
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and it encodes a protein similar to the yeast class C Vps33 protein. The mammalian class C VPS proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
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Protein Aliases: hVPS33A; vacuolar protein sorting 33 homolog A; vacuolar protein sorting 33A; Vacuolar protein sorting-associated protein 33A; VPS33A CORVET/HOPS core subunit
Gene Aliases: VPS33A
UniProt ID: (Human) Q96AX1
Entrez Gene ID: (Human) 65082
Molecular Function: membrane trafficking regulatory protein