Immunogen sequence: QHELSESCSA SALQARLKVA AHEAEEESDN IAEDFLEGKM EIDDFLSSFM EKRTICHCRR AKEEKLQQAI AMHSQFHAPL
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53.
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Protein Aliases: ESCRT-I complex subunit VPS37A; HCRP1; Hepatocellular carcinoma-related protein 1; hVps37A; polyglutamine binding protein 2; vacuolar protein sorting 37 homolog A; Vacuolar protein sorting-associated protein 37A
Gene Aliases: HCRP1; PQBP2; SPG53; VPS37A
UniProt ID: (Human) Q8NEZ2
Entrez Gene ID: (Human) 137492