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Proteintech
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Immunogen sequence: ERTVQYLQH LGTENLHLIF SYSVWVLRDF PEDGLKIFTE DLPEVESLPR DRVLGFLIEN FKGLAIPYLE HIIHVWEETG SRFHNCLIQL YCEKVQGLMK EYLLSFPAGK TPVPAGEEEG ELGEYRQKLL MFLEISSYYD PGRLICDFPF DGLLEERALL LGRMGKHEQA LFIYVHILKD TRMAEEYCHK HYDRNKDGNK DVYLSLLRMY LSPPSIHCLG PIKLELLEPK ANLQAALQVL ELHHSKLDTT KALNLLPANT QINDIRIFLE KVLEENAQKK RFNQVLKNLL HAEFLRVQEE RILHQQVKCI ITEEKVCMVC KKKIGNSAFA RYPNGVVVHY FCSKEVNPAD T (537-886 aa encoded by BC015817)
VPS39 is the mammalian homolog of the yeast vacuolar protein VAM6, that in mammals, promotes lysosome clustering and fusion in vivo. VPS39 is also thought to modulate the TGF-beta response by coupling the TGF-beta receptor complex to the Smad pathway. Similar to the related protein TRAP1, the VPS39 protein is essential for early embryonic development, with mice lacking VPS39 dying at or before E6. 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hVam6p; OTTMUSP00000023341; OTTMUSP00000023350; PI3K type 3; TRAP1-like protein; vacuolar protein sorting 39 homolog; Vam6/Vps39-like protein; VPS39 HOPS complex subunit
Gene Aliases: A230065P22Rik; AW743070; hVam6p; KIAA0770; mVam6; Pldn; TLP; VAM6; Vam6P; VPS39
UniProt ID: (Human) Q96JC1, (Mouse) Q922I3
Entrez Gene ID: (Human) 23339, (Mouse) 269338
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