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Invitrogen
VPS39 Polyclonal Antibody
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Product Details
PA5-21104
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide near the carboxy terminus of human VPS39.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is rat liver tissue lysate.
PA5-21104 can be used with blocking peptide PEP-1218.
Target Information
VPS39 is the mammalian homolog of the yeast vacuolar protein VAM6, that in mammals, promotes lysosome clustering and fusion in vivo. VPS39 is also thought to modulate the TGF-beta response by coupling the TGF-beta receptor complex to the Smad pathway. Similar to the related protein TRAP1, the VPS39 protein is essential for early embryonic development, with mice lacking VPS39 dying at or before E6. 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hVam6p; OTTMUSP00000023341; OTTMUSP00000023350; PI3K type 3; TRAP1-like protein; unnamed protein product; vacuolar protein sorting 39 homolog; Vam6; Vam6/Vps39-like protein; VPS39, HOPS complex subunit
Gene Aliases: A230065P22Rik; AW743070; hVam6p; KIAA0770; mVam6; Pldn; TLP; VAM6; Vam6P; VPS39
UniProt ID: (Human) Q96JC1, (Mouse) Q8R5L3
Entrez Gene ID: (Human) 23339, (Rat) 362199, (Mouse) 269338
intracellular protein transport
vesicle-mediated transport
regulation of catalytic activity
transport
protein transport
autophagy
endosome to lysosome transport
endocytic recycling
endosomal vesicle fusion
regulation of SNARE complex assembly
autophagosome-lysosome fusion
late endosome to lysosome transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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