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Immunogen sequence: KENQSEGKG SDSDSEGDNP EKKKLQEQLM GAVVMEKPNI RWNDVAGLEG AKEALKEAVI LPIKFPHLFT GKRTPWRGIL LFGPPGTGKS YLAKAVATEA NNSTFFSVSS SDLMSKWLGE SEKLVKNLFE LARQHKPSII FIDEVDSLCG SRNENESEAA RRIKTEFLVQ MQGVGNNNDG TLVLGATNIP WVLDSAIRRR FEKRIYIPLP EEAARAQMFR LHLGSTPHNL TDANIHELAR KTEGYSGADI SIIVRDSLMQ PVRKVQSATH FKKVCGPSRT NPSMMIDDLL TPCSPGDPGA MEMTWMDVPG DKLLEPVVCM SDMLRSLATT RPTVNADDLL KVKKFSEDFG QES (86-437 aa encoded by BC047932)
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.
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Protein Aliases: hVPS4; Protein SKD2; SKD1-homolog; vacuolar protein sorting 4a; vacuolar protein sorting factor 4A; vacuolar protein sorting protein 4a; Vacuolar protein sorting-associated protein 4A; vacuolar sorting protein 4; VPS4-1; VPS4A
Gene Aliases: 4930589C15Rik; AI325971; AW553189; SKD1; SKD1A; SKD2; VPS4; VPS4-1; vps4-A; VPS4A
Molecular Function: non-motor microtubule binding protein