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Invitrogen
VPS4A Polyclonal Antibody
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Product Details
PA5-110573
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MTTSTLQKAI DLVTKATEED KAKNYEEALR LYQHAVEYFL HAIKYEAHSD KAKESIRAKC VQYLDRAEKL KDYLRSKEKH GKKPVKENQS EGKGSDSDSE GDNPEKKKLQ EQLMGAVVME
Target Information
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AAA-type ATPase; hVPS4; Protein SKD2; SKD1-homolog; unnamed protein product; vacuolar protein sorting 4a; vacuolar protein sorting factor 4A; vacuolar protein sorting protein 4a; Vacuolar protein sorting-associated protein 4A; vacuolar sorting protein 4; VPS4-1; vps4a; Walker-type ATPase
Gene Aliases: 4930589C15Rik; AI325971; AW553189; CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1; vps4-A; VPS4A
UniProt ID: (Human) Q9UN37, (Rat) Q793F9, (Mouse) Q8VEJ9
Entrez Gene ID: (Human) 27183, (Rat) 246772, (Mouse) 116733
nucleotide binding
protein binding
ATP binding
hydrolase activity
ATPase activity
macromolecular complex binding
ATP-dependent protein disaggregase activity
protein C-terminus binding
microtubule-severing ATPase activity
Rho GTPase binding
protein domain specific binding
non-motor microtubule binding protein
actomyosin contractile ring contraction
plasma membrane repair
protein targeting to lysosome
membrane budding
autophagy
nucleus organization
nuclear envelope organization
endosome organization
vacuole organization
lysosomal transport
mitotic metaphase plate congression
mitotic nuclear envelope reassembly
regulation of G2/M transition of mitotic cell cycle
protein transport
vesicle-mediated transport
endosomal transport
macroautophagy
viral release from host cell
nuclear envelope reassembly
intracellular cholesterol transport
negative regulation of cytokinesis
regulation of protein localization
endosomal vesicle fusion
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
mitotic cytokinesis checkpoint
viral budding from plasma membrane
protein depolymerization
cell division
cytoskeleton-dependent cytokinesis
late endosomal microautophagy
late endosome to lysosome transport via multivesicular body sorting pathway
midbody abscission
multivesicular body sorting pathway
vesicle uncoating
membrane fission
ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
autophagosome maturation
regulation of protein localization to plasma membrane
positive regulation of exosomal secretion
positive regulation of viral budding via host ESCRT complex
ESCRT complex disassembly
ESCRT III complex disassembly
cell separation after cytokinesis
metabolic process
abscission
cytoplasmic microtubule organization
transport
cell cycle
positive regulation of viral process
positive regulation of viral release from host cell
positive regulation of viral life cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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