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Invitrogen
VPS4A Polyclonal Antibody
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Product Details
PA5-50861
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide of human vacuolar protein sorting 4 homolog A (S. cerevisiae)
Conjugate
Form
Liquid
Concentration
2.8 mg/mL
Amount
280 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total VPS4A protein.
Target Information
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AAA-type ATPase; hVPS4; Protein SKD2; SKD1-homolog; unnamed protein product; vacuolar protein sorting factor 4A; Vacuolar protein sorting-associated protein 4A; vacuolar sorting protein 4; VPS4-1; Walker-type ATPase
Gene Aliases: CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1; VPS4A
UniProt ID: (Human) Q9UN37
Entrez Gene ID: (Human) 27183
actomyosin contractile ring contraction
plasma membrane repair
protein targeting to lysosome
membrane budding
autophagy
nucleus organization
nuclear envelope organization
endosome organization
vacuole organization
lysosomal transport
mitotic metaphase plate congression
mitotic nuclear envelope reassembly
regulation of G2/M transition of mitotic cell cycle
protein transport
vesicle-mediated transport
endosomal transport
macroautophagy
viral release from host cell
nuclear envelope reassembly
intracellular cholesterol transport
negative regulation of cytokinesis
regulation of protein localization
endosomal vesicle fusion
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
mitotic cytokinesis checkpoint
viral budding from plasma membrane
protein depolymerization
cell division
cytoskeleton-dependent cytokinesis
late endosomal microautophagy
late endosome to lysosome transport via multivesicular body sorting pathway
midbody abscission
multivesicular body sorting pathway
vesicle uncoating
membrane fission
ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
autophagosome maturation
regulation of protein localization to plasma membrane
positive regulation of exosomal secretion
positive regulation of viral budding via host ESCRT complex
ESCRT complex disassembly
ESCRT III complex disassembly
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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