Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ANG2; ANG3; Another new gene 2 protein; C11orf3; FFR; PP5382; Protein fat-free homolog; vacuolar protein sorting 51 homolog; Vacuolar protein sorting-associated protein 51 homolog; VPS51 GARP complex subunit
Gene Aliases: 1110014N23Rik; 3110057M17Rik; AI837850; ANG2; ANG3; C11orf2; C11orf3; FFR; PP5382; VPS51