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Proteintech
VPS53 Polyclonal Antibody
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Product Details
12824-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
VPS53 Fusion Protein Ag3518 (1-128 aa encoded by BC029560)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MVLLDLPSI SSQVVRKAPA SYTKIVVKGM TRAEMILKVV MAPHEPLVVF VDNYIKLLTD CNTETFQKIL DMKGLKRSEQ SSMLELLRQR LPAPPSGAES SGSLSLTAPT PEQESSRIRK LEKLIKKRL (1-128 aa encoded by BC029560 )
Target Information
The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hepatocellular carcinoma suppressor 1; hVps53L; unnamed protein product; Vacuolar protein sorting-associated protein 53 homolog; VPS53, GARP complex subunit
Gene Aliases: 2010002A08Rik; 2310040I21Rik; 3100002B05Rik; HCCS1; hVps53L; PCH2E; PP13624; RGD1311391; VPS53
UniProt ID: (Human) Q5VIR6, (Mouse) Q8CCB4
Entrez Gene ID: (Human) 55275, (Mouse) 68299, (Rat) 287535
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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