Immunogen sequence: LRDACLVANI LDPRIKQEII KKFIKQHLSE YLVLFQENQD VAWLDKIDRR YAWIKRQLVD YEEKYGRMFP REWCMAERIA VEFCHVTRAE LAKIMRTRAK EIEVKLL
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 94%.
The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Vacuolar protein sorting-associated protein 53 homolog; VPS53 GARP complex subunit
Gene Aliases: HCCS1; hVps53L; PCH2E; PP13624; VPS53
UniProt ID: (Human) Q5VIR6
Entrez Gene ID: (Human) 55275