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Proteintech
VPS72 Polyclonal Antibody
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Product Details
15143-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
VPS72 Fusion Protein Ag7424 (1-364 aa encoded by BC003151)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSLAGGRAP RKTAGNRLSG LLEAEEEDEF YQTTYGGFTE ESGDDEYQGD QSDTEDEVDS DFDIDEGDEP SSDGEAEEPR RKRRVVTKAY KEPLKSLRPR KVNTPAGSSQ KAREEKALLP LELQDDGSDS RKSMRQSTAE HTRQTFLRVQ ERQGQSRRRK GPHCERPLTQ EELLREAKIT EELNLRSLET YERLEADKKK QVHKKRKCPG PIITYHSVTV PLVGEPGPKE ENVDIEGLDP APSVSALTPH AGTGPVNPPA RCSRTFITFS DDATFEEWFP QGRPPKVPVR EVCPVTHRPA LYRDPVTDIP YATARAFKII REAYKKYITA HGLPPTASAL GPGPPPPEPL PGSGPRALRQ KIVIK (1-364 aa encoded by BC003151)
Target Information
Vacuolar protein sorting-associated protein 72 homolog (VPS72), also known as VPS72 or Transcription factor-like 1, is a 364 amino acid subunit of the TRRAP/TIP60 HAT complex. VPS72 has also been identified as a subunit of a novel complex containing SNF2-related helicase SRCAP (SWI2/SNF2-related CBP activator protein). This SRCAP-containing complex is very similar to the S. cerevisiae SWR1 chromatin remodeling complex. The involvement of VPS72 in these complexes has suggested that VPS72 plays multiple roles in chromatin modification and remodeling in cells. VPS72 localizes to the nucleus and is phosphorylated upon DNA damage, most likely by ATM or ATR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Protein YL-1; T YL-1; Transcription factor-like 1; transformation suppressor gene YL-1; unnamed protein product; Vacuolar protein sorting-associated protein 72 homolog
Gene Aliases: CFL1; Swc2; TCFL1; VPS72; YL-1; YL1
UniProt ID: (Human) Q15906, (Mouse) Q62481
Entrez Gene ID: (Human) 6944, (Rat) 310661, (Mouse) 21427
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
somatic stem cell population maintenance
regulation of apoptotic process
positive regulation of gene expression, epigenetic
positive regulation of transcription, DNA-templated
regulation of cell cycle
positive regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair
biological_process
transcription, DNA-templated
chromatin modification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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