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Immunogen sequence: EEIYPYIRTL LHFDTREFLN VLALTFEDFK NDKQAVEYQQ RIVDILLKVM VENSDFTPSQ VGCLFTFLAR QLA
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: vacuolar protein sorting 8 homolog; Vacuolar protein sorting-associated protein 8 homolog; VPS8 CORVET complex subunit
Gene Aliases: KIAA0804; VPS8
UniProt ID: (Human) Q8N3P4
Entrez Gene ID: (Human) 23355
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